Workshop – Guinea pig models of asthma

May 29 – 30, 2017

Theme:   Back to the future-  Re-establishing the guinea pig asthma model
Place:      VILLA ASKE KONFERENSER, Aske allé 2, 197 92 Bro (close to Stockholm and Arlanda airport)

Guinea pigs share striking homology with humans and are recognized as a preferred model for allergic asthma and COPD research. The anatomy their lungs, inflammatory mediator profiles (release of histamine and leukotrienes), pharmacology receptors and pathophysiology are often evoked to highlight their translational advantages.

Unfortunately, working with guinea pigs can be quite challenging. Guinea pigs exhibit pronounced airway hyperreactivity and heightened sensitivity to anaphylactic shock. Moreover, the cost of the animals, reagents and limited availability of specialized instrumentation further limit their adoption as a research model. To alleviate some of these scientific challenges achieve higher standards of research, Dr.Mikael Adner from the Karolinska Institute is hosting a workshop on guinea pig models of asthma.

Monday, 29th May 2017
12:00 – 13:00    Registration and a small buffet
13:00 – 13:10    Welcome – Mikael Adner
13:10 – 13:50    Physiology/pharmacology in guinea pigs – Professor Brendan J. Canning, Johns Hopkins Asthma and Allergy Center, Baltimore
13:40 – 14:20    A guinea pig model of acute and chronic asthma using permanently instrumented and unrestrained animals. Professor Herman Meurs, University of Groningen
14:20 – 15:00    Acute and chronic asthma models for guinea pigs – Professor Kenneth Broadley, Cardiff University
15:00 – 15:55    Coffee and checking in
15:55 – 16:00    Introduction to break-out groups – Professor Sven-Erik Dahlén/Mikael Adner
16:00 – 16:30    Pharmacological studies in guinea pig asthma models – Professor Reinoud Gosens, University of Groningen
16:30 – 17:00    Role of allergic inflammation on airway hyperresponsiveness – Post-doc Patricia Ramos Ramires, Karolinska Institutet
17:00 – 17:30    Challenges with lung function measurements- Professor Lennart Lundblad, Vermont University
17:30 – 18:30    Break-out discussion I
19:30   Dinner

Tuesday, 30th May 
08:30 – 09:15    Guinea pig asthma models for studies of cough – Professor Maria Belvisi, Imperial College, London
09:15 – 09:45    Human parainfluenza type 3 virus impairs the efficacy of glucocorticoids to limit allergy-induced pulmonary inflammation in guinea-pigs – Dr William Ford, Cardiff University
09:45 – 10:15    A new HDM-based guinea pig model of asthma – Associate professor Mikael Adner, Karolinska Institutet
10:00 – 10:30    Coffee and checking out
10:30 – 11:30    Break-out discussions II
11:30 – 12:00    General discussion of the outcome from the groups 1
12:00 – 13:00    Lunch
13:00 – 14:30    General discussion of the outcome from the groups, and structure of the paper.
14:30 – 15:00    Concluding remarks – Mikael Adner, Sven-Erik Dahlén, Gunnar Nilsson

Registration deadline 12th May.

If you wish to attend or would like more information about the workshop contact .


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