Wire myograph systems

The measurement of microvessels contractility following drug administration is widely used in preclinical research.

Our myograph systems are suitable for the study of microvessels, such as veins, small arteries, lymph vessels and tracheal smooth muscle.

Oxygenated and nutrient-rich perfusate is provided to tissues with lumen diameter from 100µm to 3mm and segment lengths up to 3.5mm, while allowing the investigation of vascular function following drug challenges.

Our product line includes:

emkaMYO2, driven manually and equipped with 1 or 2 myograph modules
emkaBATH4, automated system equipped with up to 4 myograph modules

Benefits

Easy to operate

Modular

Real-time analysis

Description

Compact and modular systems

Available in single (MYO1), dual (MYO2) or with four myograph modules (emkaBATH4)
Equipped with itMYO2 isometric transducer
Small bath volume of 5 ml
Vessels are mounted on tungsten wire
Precision vernier positioner for tissue tension
emkaBATH4 can also be used for tissue studies in tubular baths. Learn more

Easy to use

Easy access to the tissue
Monobloc myograph bath for easy cleaning
Integrated transducers and amplifiers
Manual tissue tensioning
Automated bath emptying
Bath temperatures adjusted & controlled electronically
MYO1 can be upgraded with two myograph modules
Myograph module can be used indifferently on emkaMYO2 or emkaBATH4

Which model to choose?

emkaMYO2 is ideal for education:

Compact
Easy to install, to use and store
Touchscreen for information display and simple settings
Automatic emptying

emkaBATH4 answers your more complex requirements, with:

Up to 16 myograph modules automatically managed by a single computer
In-line electric heating
Automatic bath filling and emptying
Bath overflow, to remove any risk of dry-out (tissue is never exposed to air)
Ability to switch from tubular to microvessel baths in a few minutes

How data is acquired and analyzed

Each myograph module is equipped with two jaws, a transducer and a Vernier positioner. Each jaw holds a piece of tungsten wire on which the vessel is mounted (parallel wires are passed through the vessel lumen).

Tissue pretensioning is done by the precision Vernier positioners. The force of muscular contraction is transmitted to the transducer.

Measured tension is acquired by iox2 software, which provides:

Detailed calculation on slow contracting tissue
Full data display as graph, tables or trends
On-the-fly comment and mark addition
A normalization module

Calculated parameters generated by iox2 software can be automatically processed by datanalyst software, to provide statistics such as data group averaging, ED50…, presented in concise tabular format.