Plethysmography is a standard method for studying pulmonary function in laboratory rodents. The barometric plethysmography technique measures flow and pressure changes that occur while the subject is breathing, before and after exposure to a drug or other challenges. It is easily adapted to various subject sizes and species, and is often used for longitudinal studies where the subjects are studied for multiple hours on successive experiment days.
Learn more about our plethysmographs on our website dedicated to respiratory research.
Testing Acute Oxygen Sensing in Genetically Modified Mice: Plethysmography and Amperometry
Ortega-Sáenz et al, Hypoxia: Methods and Protocols, Methods Mol Biol. 2018
V0162 a new long-acting bronchodilator for treatment of chronic obstructive lung diseases: preclinical and clinical results
Devillier et al. Respiratory Research, 2015
Assessment of Respiratory Function in Conscious Mice by Double-Chamber Plethysmography
Samuel Mailhot-Larouche et al, Journal of Visualized Experiments, 2018
The novel μ-opioid receptor agonist PZM21 depresses respiration and induces tolerance to antinociception
Rob Hill et al, Br J Pharmacol. 2018;175(13):2653-2661. doi:10.1111/bph.14224