Non-invasive systems for rodents

We offer three systems for non-invasive measurement of cardiovascular parameters on rodents:

  • ecgTUNNEL, a plug-and-play system for snapshot ECG recordings and respiration data 
  • rodentPACK, in backpack configuration, to record 1 or 2-lead ECG and activity 
  • CODA system, to performs blood pressure measurements from the tail cuff of the animal 

Benefits

1

Non-invasive

2

Quick and easy setups

3

Rapid adaptation

Description

ecgTUNNEL, for non-invasive ECG & respiration

ecgTUNNEL combines up to 6-lead ECG with an optional plethysmograph dome for respiratory endpoints with optional exposure and infusion options, in rodents from 15g to 800g. 

This set up is particularly useful for snapshot recordings during sessions lasting a few minutes. It is often used for longitudinal studies where the subjects are studied on successive experiment days, or when subjects are particularly fragile and cannot tolerate surgery or anesthesia.

In an interview, Kimberly Londer BS, from the University of Maryland, said “there are few systems, publications, or data that exists on small animal ECG without the use of anesthesia or telemetry.”

Clean, reproducible data

The system consists of a base with 4 electrode pads and a restraining tunnel.

Restrained subjects quickly acclimate to their environment and often fall asleep, reducing the stress artifact in the ECG. These snapshot recordings (up to a couple hours) are easy to acquire and reproduce.

Easy to use

ecgTUNNEL allows you to avoid complications or adverse side effects encountered with the use of anesthesia, implantation, or at-risk/fragile models, favoring experiments that comply with the 3R’s and IACUC* protocols.

High throughput screening for phenotyping, model development, disease progression, drug effects, etc. allows for efficient and costeffective assessment of large cohorts.

A single PC can connect 1 to 8 ecgTUNNELs with a simple plug-and-play USB connection.

*Institutional Animal Care and Use Committee

 

Quick analysis

Acquire and analyze large data files in minutes for heart rate, interval computation and respiratory parameters (rates, durations, breathing depth, degree of bronchoconstriction) or more advanced uses such as arrhythmia detection and heart rate variability (HRV). 

rodentPACK, for non-invasive ECG

rodentPACK is a telemetry system to investigate biopotentials and acceleration on freely moving animals 50g and upwards, such as rats.

It may be fixed to the cranium for neuro cardiovascular studies, or worn in a jacket and fitted with miniature ECG cables and skin electrodes, for non-invasive ECG recordings. In backpack configuration, it allows non-invasive recording of:

  • 1 or 2-lead ECG (2, 3 or 4 electrode cables)
  • x/y/z and global acceleration for postural and activity assessment

Freely moving subjects

Digital telemetry receivers are positioned in the animals’ room, within 3 to 5 meters distance from their associated transmitters. Each subject is therefore free to move, single or group-housed in its cage, during the acquisition (up to 32 rats in the same room with no required shielding). The whole system is compact, as a single receiver can communicate with up to 4 transmitters. Receivers are powered and transmit data through a single Ethernet cable.

Simple design at low cost

Transmitters are reusable across subjects, cohorts, and studies, reducing total system cost. Batteries permit up to 6+ days of continuous acquisition and can be replaced at minimal cost.



CODA, for Non-Invasive Blood Pressure (NIBP)

The volume-pressure recording technology used in the sensors is clinically validated and provides virtually 100% correlation with direct blood pressure measurements.

The CODA™ system includes:

  • A custom platform with an animal holder, a cuff and a warming pad
  • A controller with automatic inflation/deflation feature
  • A data acquisition software with automatic blood pressure measurements
  • A specially designed pump to rapidly and automatically coordinate the occlusion cuff inflation and deflation cycles with the blood pressure signal acquisition.
  • 4 models are available:

    • CODA MonitorTM , for 1 animal (integrated display & software, no computer needed)
    • CODA™ 4, 6 or 8  system, for the study of up to 4, 6 or 8 animals

    The supplied software allows real-time monitoring of parameters and can simultaneously acquire measurements from 48 animals (six CODA 8 systems). Six blood pressure parameters are acquired in rodents (from 8 g mice to rats as large as 950 g, dark-skinned mice (C57BL/6) without difficulty): 

    • Systolic blood pressure
    • Diastolic blood pressure
    • Mean blood pressure
    • Heart rate
    • Blood flow
    • Blood volume

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