Non-invasive systems for large animals
emkaPACK4G is a non-invasive telemetry system to monitor heart rate and vascular effects following drug challenges, in large animals, such as dogs, primates, sheep or minipigs.
This wireless system can be used on freely moving subjects, for long-term recordings, whith an external transmitterworn into a jacket.
It can also be used for snapshot measurements, without jacket, which is especially useful for short term cardiotoxicity studies.
Impossible data cross-talk
Non-invasive and reliable data
Physiological measurements are captured non-invasively and wirelessly transmitted by Bluetooth to a receiver. Bluetooth data transmission prevents any data cross-talk, allowing each subject to freely to move, single or group-housed in its room, during the acquisition (max. 32 to 48 subjects per room).
Advantages associated with this technique is obvious and well known: longer and better quality data obtained from less stressed subjects, allowing compliance with 3Rs principles.
With emkaPACK4G system, we offer 48 to 72 hours of continuous transmission on same batteries.
Modular and compact infrastructure
Up to 9-lead ECG, recorded by external electrodes and Non-invasive blood pressure (NIBP), recorded by oscillometry, with an inflatable cuff placed on limb or tail are simultaneously acquired.
Additional signals are available as optional adds-on, so you buy only what you need and can upgrade at any time:
- Lung volume
- Posture and activity
The whole system is compact, with one or several telemetry receivers, positioned in the animals’ room, within 10 meters distance from their associated transmitters. A single receiver can communicate with up to 16 transmitters, and is powered and transmits data through a single Ethernet cable.
Data acquisition & analysis
Using the pioneering shape recognition techniques, ecgAUTO is able to analyze normal or abnormal ECG morphology. Single or multi-lead analysis provides beat-by-beat calculation of intervals (RR, QRS, QT), amplitude, signal elevation, area etc. A range of advanced features is also available, such as arrhythmia detection, Heart Rate Variability analysis and many more.
NIBP module not only provides parameters values (systolic, diastolic and mean blood pressure, amplitude, heart rate) but also shows how data where analyzed, through a detailed panel. This panel allows you to understand your results and, if necessary, to manually invalidate some irrelevant data points.
emkaPACK4G takes full advantage of emka TECHNOLOGIES software suite with:
Toxicological testing of allogeneic secretome derived from peripheral mononuclear cells (APOSEC): a novel cell-free therapeutic agent in skin disease
SilvioWuschko et al, Scientific Reportsvolume 9, Article number: 5598 (2019)
Involvement of peroxisome proliferator-activated receptors in cardiac and vascular remodeling in a novel minipig model of insulin resistance and atherosclerosis induced by consumption of a high-fat/cholesterol diet
Yongming et al - Cardiovascular Diabetology 14:6, 2015
Assessment of non-invasive telemetric blood pressure and electrocardiogram measurement in conscious dogs
Poster presented by GlaxoSmithKline, Society of Toxicology meeting, 2011
Development of a methodology to measure the effect of ergot alkaloids on forestomach motility using real-time wireless telemetry
Egert et al, Frontiers in chemistry, 2014
Evaluation of oscillometric and vascular access port arterial blood pressure measurement techniques versus implanted telemetry in anesthetized cats
Raphael J. Zwijnenberg et al. AJVR Vol 72, No. 8, August 2011
Inclusion of Blood Pressure Measurements in Canine Toxicology Studies
Emily Bailey et al, Poster presented by AstraZeneca, 2011