Non-invasive ECG for large animals
emkaPACK4G is a non-invasive telemetry system to monitor heart rate following drug challenges, in large animals such as dogs, primates, sheep or minipigs.
This wireless system can be used on freely moving subjects, for long-term recordings, whith an external transmitter worn into a jacket.
It can also be used for snapshot measurements, without jacket, which is especially useful for short term cardiotoxicity studies.
Impossible data cross-talk
Non-invasive and reliable data
Physiological measurements are captured non-invasively and wirelessly transmitted by Bluetooth to a receiver. Bluetooth data transmission prevents any data cross-talk, allowing each subject to freely to move, single or group-housed in its room, during the acquisition (max. 32 to 48 subjects per room).
Advantages associated with this technique is obvious and well known: longer and better quality data obtained from less stressed subjects, allowing compliance with 3Rs principles.
With emkaPACK4G system, we offer 48 to 72 hours of continuous transmission on same batteries.
Modular and compact infrastructure
Up to 9-lead ECG recorded by external electrodes is acquired. Additional signals are available as optional adds-on, so you buy only what you need and can upgrade at any time with:
- Blood pressure
- Lung volume
- Posture and activity
The whole system is compact, with one or several telemetry receivers, positioned in the animals’ room, within 10 meters distance from their associated transmitters. A single receiver can communicate with up to 16 transmitters, and is powered and transmits data through a single Ethernet cable.
Data acquisition & analysis
Electrocardiogram acquisition and real-time analysis is performed by IOX2 software. Further in-depth ECG analysis is offered in ecgAUTO software.
Using the pioneering shape recognition techniques, ecgAUTO is able to analyze normal or abnormal ECG morphology. Single or multi-lead analysis provides beat-by-beat calculation of intervals (RR, QRS, QT), amplitude, signal elevation, area etc. A range of advanced features is also available, such as arrhythmia detection, Heart Rate Variability analysis and many more.
emkaPACK4G takes full advantage of emka TECHNOLOGIES software suite with:
- Easy & seamless calibration of all signals
- Synchronized video
- GLP tools, audit trail and electronic signature
- Global study data organization and management
Toxicological testing of allogeneic secretome derived from peripheral mononuclear cells (APOSEC): a novel cell-free therapeutic agent in skin disease
SilvioWuschko et al, Scientific Reportsvolume 9, Article number: 5598 (2019)
Involvement of peroxisome proliferator-activated receptors in cardiac and vascular remodeling in a novel minipig model of insulin resistance and atherosclerosis induced by consumption of a high-fat/cholesterol diet
Yongming et al - Cardiovascular Diabetology 14:6, 2015
Assessment of non-invasive telemetric blood pressure and electrocardiogram measurement in conscious dogs
Poster presented by GlaxoSmithKline, Society of Toxicology meeting, 2011