Implants for mice
easyTEL is a fully implantable telemetry system, that transmits physiological data from conscious freely moving small subjects weighing 20 g or more, single-housed.
Intended for use in preclinical research, easyTEL-S size implants are ideal for mice and offer the ability to continuously record:
- Biopotential (ECG, EEG, EMG, EOG)*,
- Respiratory rate**,
- Core Body Temperature
*Electrocardiogram (ECG), electroencephalogram (EEG), electromyography (EMG), electrooculography (EOG)
**Derived from pleural or blood pressure, or diaphragmatic EMG
***Derived from x,y,z acceleration data
Clean & synchronized data
Long term studies
Simple and cost effective design
Clean and synchronized data
Telemetry represents the only technique currently available for data collection from unrestrained, freely moving mice.
Through the use of telemetry, it is possible to gather data continuously, for longer periods of time, from animals residing in their own familiar environment, thus minimizing stress to the animals and consequent experimental artifacts. Furthermore, in vivo studies from conscious, unanesthetized, instrumented animals are recommended by the FDA for ICH S7A studies.
The easyTEL system can simultaneously collect signals from implants, analog signals, biopotential electrodes and/or strain gauge transducers. This is particularly useful for neurorespiratory or cardiorespiratory applications. For example pleural pressure from an implant and respiratory flow from a head-out plethysmograph can be simultaneously recorded, for precise resistance & compliance measurement.
Long term studies
Wireless implanted telemetry provides the unique ability to discover and review long-term physiological trends, as well as rare or isolated physiological events (arrhythmias, seizures, etc.).
Our implanted telemetry permits continuous data recording up to 90 days, with up to 64 single-housed mice per system.
Cardiotoxicity studies can also benefit from telemetry as was highlighted by Hoay Yan Cheah et al. Telemetry can be used in nanotoxicology to assess physiology in animals exposed to nanoparticles. As Hoay Yan Cheah says, “Telemetry provides an unlimited capacity for continuous data acquisition over days, weeks or even months“.
Simple and cost-effective design
Implants are priced for single use, eliminating the need for refurbishment and associated logistics, costs, and delays (implants can be re-implanted as long as battery lasts).
A single device monitors ambient pressure, handles data and power, and connects to the computer.
Software acquisition & analysis
Technique & measurements
Physiological measurements are captured and amplified by a transmitter surgically implanted. The signal is then wirelessly transmitted to a receiver, placed under the cage. The easyMATRIX3 device, placed between the receiver and the computer, digitizes and encodes the signals that are sent to the acquisition computer running IOX2 software.
Configuration & extensions
A typical setup includes:
- Implants: to capture physiological measurements
- Receivers: For mice, one receiver per implant is placed below the cage, to receive physiological signals wirelessly transmitted
- A computer: equipped with IOX2 acquisition software
- An easyMATRIX3: Linked to the computer, capable of connecting to up to 16 telemetry receivers and 8 analog inputs (Up to 4 easyMATRIX3 connect to a single computer).
easyMATRIX3 contains its own ambient pressure transducer, requiring no external ambient pressure reference monitor.
Up to 8 analog signals can be simultaneously acquired and synchronized with signals coming from the implant. Additional transducers are therefore added to the basic system:
- Biopotential electrodes, for ECG, EEG, or EMG recording (signal is amplified by easyMATRIX3)
- Strain gauge transducers (differential pressure or blood pressure transducers), powered and amplified by easyMATRIX3
- Analog signals already amplified (connected through Lemo-BNC adapters)
|Implant weight (g)||Animal weight|
|*Battery life refers to days of continuous recording.|
easyTEL also offer M size implants, designed for medium subjects weighing 100g or more.