Implants for large animals

easyTEL+ is a fully implantable digital system, that transmits physiological data from conscious freely moving laboratory animals. It can be remotely managed and configured.

Intended for use in preclinical research (primarily toxicology, phar­macology and safety pharmacology studies) and biodefense, the easyTEL+ implants are ideal for large animals > 1 kg such as rabbits, swine, dogs or primates.

Various models offer the ability to continuously record:

  • Biopotential (ECG, EEG, EMG, EOG)*
  • Blood pressure (Arterial and/or Left Ventricular Pressure)
  • Respiratory rate**
  • Temperature
  • Acceleration from 3-axis accelerometer (activity)

*Electrocardiogram (ECG), electroencephalogram (EEG), electromyography (EMG), electrooculography (EOG)
**Derived from pleural or blood pressure or diaphragmatic EMG

Benefits

Customizable & remote control

Clean data

Simple design & cost effective

Description

Customizable

easyTEL+ implanted telemetry is a customizable system, easy to implement and to manage, offering continuous reliable data recording during up to 285 days.

A variety of physiological signals, including biopotentials, blood pressure,    rate, temperature, and postural activity data can be recorded, depending on the implant model.

Optional synchronized signals, including video and non-invasive endpoints, can be combined with easyTEL+ system (see configuration & extension section).

Clean data

Up to 32 animals can be group-housed in the same room or cage, with no cross talk. Group-housing advantages include reduced stress and subject socialization, helping with the 3R’s* of research. 

Quality of Signal (QoS) is available as its own signal, continuously monitoring the connection quality between the implant and the acquisition PC, and quickly detecting any change in the radiofrequency environment. QoS can be used to automatically differentiate between true events and data loss to avoid incorrect analysis (i.e. long RR intervals).

Solid-tip electrodes are available, providing an intravascular ECG with a better signal to noise ratio compared to subcutaneous placement, while avoiding the thoracotomy required in an epicardial surgery.

*Replacement, reduction, refinement

Remote control
  • Easily control implant state (on/off) without subject interaction.
  • Use default settings or wirelessly customize sampling rate, resolution, power, transmission frequency, etc. before and after implantation.
Simple design and cost effective

easyTEL+ system design is compact, with a direct receiver-computer link, and easy to use, with no external antenna and a collar on Left Ventricular Catheter, for an easier implantation.

Implants are priced for a single use, eliminating the need for refurbishment and associated logistics (implants can be re-implanted as long as battery lasts).

Techniques & measurement

Physiological measurements are captured by a transmitter surgically implanted and wirelessly transmitted to a receiver within 3 to 5 meters distance.
With emka digital telemetry, the signal is already digitized by the transmitter. Therefore, when received by the telemetry receiver, it can be directly sent to the acquisition computer, via Ethernet.

Wireless technology is ideal to reliably transfer high volumes of data from a freely moving animal. Advantages associated with this technique are well known: Longer and better-quality data obtained from less stressed subjects, allowing compliance with 3Rs principles*.

Wireless implanted telemetry provides the unique ability to look into long-term physiological trends, as well as rare or isolated physiological events (arrhythmias, seizures, etc.).

*Replacement, reduction, refinement

 

Configuration & extensions

A typical setup includes implants, receivers, an ethernet switch and an acquisition comptuer. A single ethernet cable provides power and data transmission between the receiver and PC.

Optional synchronized signals include video and non-invasive endpoints.

easyTEL+ can be combined with the non-invasive emkaPACK4G system, on the same platform.
It can be beneficial when lung volumes need to be recorded.

Software acquisition & analysis

easyTEL system runs with IOX2 software for signal acquisition and real time analysis.

ecgAUTO serves as a single analysis platform with à la carte modules to meet your unique analysis needs. Cardiovascular, neurological, and respiratory analysis utilize custom parameters and protocols to produce comprehensive data reports. Additional, advanced modules are available for interval analysis, arrhythmia and seizure detection, heart rate variability, and more.

Technical specifications

L size implants are larger and offer a higher battery life while M2 size implants are smaller, to be used for toxicology studies.

easyTEL Biopotential Pressure Temperature Activity Battery life*
(days) 
Volume
(cc)
Animal weight 
+L-TA 1 1 285 29 >1kg
+L-PTA 1 1 1 190 29 >1kg
+L-ETA 1   1 1 160 29 >1kg
+L-EPTA 1 1 1 1 110 29 >1kg
+L-EPPTA 1 2 1 1 80 29 >1kg
+L-EEPTA 2 1 1 1 85 29 >1kg
+L-EEPPTA 2 2 1 1 60 29 >1kg
+L-EEEETA 4   1 1 105
29 >1kg
+M2-TA   1 1 150 12.5 >1kg
+M2-PTA 1 1 1 60 12.5 >1kg
+M2-ETA 1   1 1 70 12.5 >1kg
+M2-EPTA 1 1 1 50 12.5 >1kg
*Battery life refers to days of continuous recording and is given for a data rate set to “high” and for standard sampling frequencies: Biop.: 500Hz, except EEEETA @ 250Hz; Pressure 1: 250Hz; Pressure 2: 500Hz.

 

 

 

 

Services

Support

Training

Validation

Data analysis

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