Implants for large animals
easyTEL implantable system transmits physiological data from conscious freely moving laboratory animals.
Physiological measurements are captured by a transmitter surgically implanted and wirelessly transmitted to a receiver within 3 to 5 meters distance.
Intended for use in preclinical research (primarily toxicology, pharmacology and safety pharmacology studies) and biodefense, the easyTEL+ digital range of implants, available in L and M2 sizes, are ideal for large animals such as rabbits, swine, dogs or primates
Various models offer the ability to continuously record:
- Biopotential (ECG, EEG, EMG)
- Blood pressure (Arterial and/or Left Ventricular Pressure)
- Respiratory rate*
- Acceleration from 3-axis accelerometer (activity)
*Derived from pleural or blood pressure or diaphragmatic EMG
Ease of use
When simplicity meets reliability
Choosing easyTEL+ implanted telemetry means opting for a reliable system, easy to implement and to manage:
- Up to 32 animals can be group-housed in the same room or cage
- Up to 285 days of continuous reliable data recording, with zero cross-talk and QoS recording
- M2 size implants available for your toxicology studies
- Remote implant configuration and management via software: no more magnet for implant on/off
- Single-use (non-refurbished) implants means no reconditioning, no shipping costs and delays. Implants can be re-implanted as long as battery lasts
- Compact design, with direct receiver-computer link
- Easy surgery, with no external implant antenna
- Solid-tip electrodes for noise-free ECG
- Collar for Left Ventricular Catheter
Combining implanted and non-invasive telemetry on the same platform is now possible!
The emkaPACK4G receiver can be used to receive implant signals. It can be beneficial when lung volumes need to be recorded.
Software acquisition & analysis
Compliance with 3Rs
Wireless technology is ideal to reliably transfer high volumes of data from a freely moving animal. Advantages associated with this technique are well known:
Longer and better-quality data obtained from less stressed subjects, allowing compliance with 3Rs principles.
Furthermore, in vivo studies from conscious, unanesthetized instrumented animals are recommended by the FDA for ICH S7A studies.
Wireless implanted telemetry provides the unique ability to look into long-term physiological trends, as well as rare or isolated physiological events (arrhythmias, seizures, etc.).
|*Battery life refers to days of continuous recording and is given for a data rate set to “high” and for standard sampling frequencies: Biop.: 500Hz, except EEEETA @ 250Hz; Pressure 1: 250Hz; Pressure 2: 500Hz.
And many more!
Telemetered Left-Ventricular Pressure in Yucatan Mini-Pigs: Chronic Evaluation in a Novel Genetic Model of Non-Obstructed Hypertrophic Cardiomyopathy
Beth Geist et al, poster presented at the Safety Pharmacology Society, 2018
Evaluation of Respiratory Rate Measurements Derived from Blood Pressure Waveforms in Telemetered Dogs
Hai-Ming Tang et al, Poster presented at the Safety Pharmacology Society 2018
Development of A Large Animal Model for Combined Seizure and Cardiovascular Liability Assessment
Nataliya Sadekova et al, Poster from Charles River, SPS annual meeting 2019