emkaPACK4G for large animals
emkaPACK4G is a non-invasive telemetry system, widely used in large animals studies to monitor the physiology of freely moving large animals, such as dogs, primates, sheep or minipigs,
An external transmitter is worn into a jacket and provides simultaneously:
- Lung volume
- Posture and activity
- Blood pressure
Each signal type is available as an optional add-on, so you buy only what you need and can upgrade at any time.
emkaPACK4G can also be used for ECG snapshot measurements, without jacket, which is especially useful for short term cardiotoxicity studies.
Impossible data cross-talk
Non-invasive and reliable data
Physiological measurements are captured non-invasively and wirelessly transmitted by Bluetooth to a receiver. Bluetooth data transmission prevents any data cross-talk, allowing each subject to freely to move, single or group-housed in its room, during the acquisition (max. 32 to 48 subjects per room).
Advantages associated with this technique is obvious and well known: longer and better quality data obtained from less stressed subjects, allowing compliance with 3Rs principles.
With emkaPACK4G system, we offer 48 to 72 hours of continuous transmission on same batteries.
Modular and compact infrastructure
Up to 17 signals can be recorded simultaneously from each animal, through various sensors plugged to the transmitter:
||Up to 9-lead ECG are recorded by external electrodes|
||1 or 2 belts record lung volume for Respiration measurement by Inductive Plethysmography (RIP)|
||Non-invasive blood pressure (NIBP) is recorded by oscillometry, with an inflatable cuff placed on limb or tail.
Core blood pressure is acquired from easyTEL+ implant or from a vascular access port (VAP).
||Measured by a skin electrode or an implanted probe|
||3 axis activity and total acceleration is calculated by an accelerometer.|
The whole system is compact, with one or several telemetry receivers, positioned in the animals’ room, within 10 meters distance from their associated transmitters. A single receiver can communicate with up to 16 transmitters, and is powered and transmits data through a single Ethernet cable.
Easy to setup
It only takes a few minutes to equip the animals using our custom-designed clothing for canine, primate, swine and sheep. A number of custom features are available, depending on emkaPACK4G options.
Data acquisition & analysis
emkaPACK4G takes full advantage of emka TECHNOLOGIES software suite with:
Cardiac function, myopathy, and more !
Toxicological testing of allogeneic secretome derived from peripheral mononuclear cells (APOSEC): a novel cell-free therapeutic agent in skin disease
SilvioWuschko et al, Scientific Reportsvolume 9, Article number: 5598 (2019)
Assessment of non-invasive telemetric blood pressure and electrocardiogram measurement in conscious dogs
Poster presented by GlaxoSmithKline, Society of Toxicology meeting, 2011
Development of a methodology to measure the effect of ergot alkaloids on forestomach motility using real-time wireless telemetry
Egert et al, Frontiers in chemistry, 2014
Evaluation of oscillometric and vascular access port arterial blood pressure measurement techniques versus implanted telemetry in anesthetized cats
Raphael J. Zwijnenberg et al. AJVR Vol 72, No. 8, August 2011
Inclusion of Blood Pressure Measurements in Canine Toxicology Studies
Emily Bailey et al, Poster presented by AstraZeneca, 2011
Involvement of peroxisome proliferator-activated receptors in cardiac and vascular remodeling in a novel minipig model of insulin resistance and atherosclerosis induced by consumption of a high-fat/cholesterol diet
Pan Yongming et al, Cardiovascular Diabetology 2015