Non-invasive ECG & respiration for rodents

ecgTUNNEL is a non-invasive measurement system for rodents.

It records up to 6-lead ECG signal in a few seconds, with respiration in option, from conscious neonate to adult mice and rats.

This set up is particularly useful for snapshot recordings during sessions lasting a few minutes. It is often used for longitudinal studies where the subjects are studied on successive experiment days.

Standard ECG interval can be quickly recorded, for a simple heart rate monitoring. In-depth cardiovascular function can also be explored. Main applications cover:

  • Toxicology studies
  • Early safety
  • Aging
  • Cardiac monitoring for animal well-being, pain, stress or behavior
  • Screening
  • Cardiovascular diseases, such as cardiac dystrophy or some arrhythmias (conduction problem, Ion channels …)

Benefits

1

Non-invasive

2

Quick & easy setup

3

Modular

Description

System configuration

The ecgTUNNEL is a unique system allowing continuous 6 lead ECG and respiratory measurements from up to 8 rodents simultaneously.

The system consists of 3 parts:

    • a base, which houses electronics (Direct USB link to computer) and 4 electrode pads recording up to 6-lead ECG
    • a restraining tunnel
    • an optional respiration dome with its differential pressure transducer

For respiratory studies, this setup must be completed with:

  • A respiratory dome, with a pneumotachograph and a pressure port
  • A bias flow pump for air renewal
  • A differential air pressure transducer
  • Aerosol delivery
Data analysis

IOX2 software performs acquisition and real-time analysis from up to 8 ecgTUNNELS simultaneously and provides:

  • Basic heart rate analysis
  • Respiratory rates and durations, breathing depth
  • Degree of bronchoconstriction (penH)

Post-acquisition ECG analysis, based on shape recognition technique, is done in ecgAUTO software.

  • Beat-by-beat or average beat analysis
  • Single or multilead
Kimberly Londer BS Interview

In an interview, Kimberly Londer BS, from the University of Maryland, explains how she took advantage of ecgTUNNEL to phenotype animals for various heart conditions and develop treatment options for a double transgenic mouse model with atrial fibrillation.

Applications

Early safety, Ageing, Cardiac monitoring for animal well-being, pain, stress or behavior, Screening and more!

Services

Support

Training

Validation

Data analysis

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