Non-invasive ECG & respiration for rodents
ecgTUNNEL is a non-invasive measurement system for rodents.
It records up to 6-lead ECG signal in a few seconds, with respiration in option, from conscious neonate to adult mice and rats.
This set up is particularly useful for snapshot recordings during sessions lasting a few minutes. It is often used for longitudinal studies where the subjects are studied on successive experiment days.
Standard ECG interval can be quickly recorded, for a simple heart rate monitoring. In-depth cardiovascular function can also be explored. Main applications cover:
- Toxicology studies
- Early safety
- Cardiac monitoring for animal well-being, pain, stress or behavior
- Cardiovascular diseases, such as cardiac dystrophy or some arrhythmias (conduction problem, Ion channels …)
Quick & easy setup
The ecgTUNNEL is a unique system allowing continuous 6 lead ECG and respiratory measurements from up to 8 rodents simultaneously.
The system consists of 3 parts:
- a base, which houses electronics (Direct USB link to computer) and 4 electrode pads recording up to 6-lead ECG
- a restraining tunnel
- an optional respiration dome with its differential pressure transducer
For respiratory studies, this setup must be completed with:
- A respiratory dome, with a pneumotachograph and a pressure port
- A bias flow pump for air renewal
- A differential air pressure transducer
- Aerosol delivery
IOX2 software performs acquisition and real-time analysis from up to 8 ecgTUNNELS simultaneously and provides:
- Basic heart rate analysis
- Respiratory rates and durations, breathing depth
- Degree of bronchoconstriction (penH)
Post-acquisition ECG analysis, based on shape recognition technique, is done in ecgAUTO software.
- Beat-by-beat or average beat analysis
- Single or multilead
Early safety, Ageing, Cardiac monitoring for animal well-being, pain, stress or behavior, Screening and more!
Effect of genetic background on the cardiac phenotype in a mouse model of Emery-Dreifuss muscular dystrophy
Nicolas Vignier et al, Biochemistry and Biophysics Reports Volume 19, 2019
Non-invasive restrained ECG recording in conscious small rodents: a new tool for cardiac electrical activity investigation
H. Mongue-Din et al, Eur J Physiol, 2007
Effect of metformin on ECG, HR and BP of rats administered with cardiotoxic agent doxorubicin
Emeka et al, International Journal of Basic & Clinical Pharmacology, 2017
Targeting of NAT10 enhances healthspan in a mouse model of human accelerated aging syndrome
Gabriel Balmus et al, Nature Communications, 2018
Erythrocyte-derived microvesicles induce arterial spasms in JAK2V617F myeloproliferative neoplasm
Johanne Poisson et al, J Clin Invest. 2020
Age-dependent changes in electrophysiology and calcium handling implications for pediatric cardiac research
Luther M. Swift et al, 2019