Non-invasive ECG & respiration for rodents

ecgTUNNEL is a plug-and-play system for snapshot ECG* recordings and respiration data in rodents that eliminates the need for surgery and anesthesia.

It combines up to 6-lead ECG with an optional plethysmograph dome for respiratory endpoints with optional exposure and infusion options. 

This set up is particularly useful for snapshot recordings during sessions lasting a few minutes. It is often used for longitudinal studies where the subjects are studied on successive experiment days, or when subjects are particularly fragile and cannot tolerate surgery or anesthesia.

In an interview, Kimberly Londer BS, from the University of Maryland, said, “there are few systems, publications, or data that exists on small animal ECG without the use of anesthesia or telemetry.” Using ecgAUTO, she “scan[s] an entire recording for AF, ventricular disorders and other arrhythmias of interest within seconds.*Electrocardiogram

Benefits

1

Clean, reproducible data

2

Modular & easy to use

3

Quick analysis

Description

Clean, reproducible data

The system consists of a base with 4 electrode pads and a restraining tunnel.

Restrained subjects quickly acclimate to their environment and often fall asleep, reducing the stress artifact in the ECG. These snapshot recordings (up to a couple hours) are easy to acquire and reproduce.

Modular

Single unit can accommodate multiple sized mouse (15g to 60 g) or rat (up to 800 g) studies.

Combine up to 6-lead ECG with an optional plethysmograph dome for respiratory endpoints with optional exposure and infusion options.

Quick analysis

Acquire and analyze large data files in minutes for heart rate, interval computation and respiratory parameters (rates, durations, breathing depth, degree of bronchoconstriction) or more advanced uses such as arrhythmia detection and heart rate variability (HRV). 

Easy to use

ecgTUNNEL allows you to avoid complications or adverse side effects encountered with the use of anesthesia, implantation, or at-risk/fragile models, favoring experiments that comply with the 3R’s and IACUC* protocols.

High throughput screening for phenotyping, model development, disease progression, drug effects, etc. allows for efficient and costeffective assessment of large cohorts.

A single PC can connect 1 to 8 ecgTUNNELs with a simple plug-and-play USB connection.

*Institutional Animal Care and Use Committee

Kimberly Londer BS Interview

In an interview, Kimberly Londer BS, from the University of Maryland, explains how she took advantage of ecgTUNNEL to phenotype animals for various heart conditions and develop treatment options for a double transgenic mouse model with atrial fibrillation.

Applications

Phenotyping, Drug development, Aging, Model development, Cardiac monitoring for animal well-being, pain, stress or behavior and more!

Services

Support

Training

Validation

Data analysis

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