As one of the oldest clinical indicators of disease in mammals, temperature is a crucial parameter to monitor, especially for infectious diseases where an acute fever is one of the first symptoms.
Temperature monitoring provides insight into:
» Inflammatory response
» Therapeutic response
» Immunity status and response
» Stress response
Infectious diseases such as COVID-19, influenza, plague, Ebola, and anthrax, affect multiple organ systems with a fever component. In an interview, Brent Barre from Lovelace Biomedical Research Institute explains how he currently works on multiple active SARS-CoV2 studies, using telemetry and plethysmography to look at temperature for onset of fever and respiratory outcomes on various animal models.
The easyTEL implanted telemetry system monitors and captures in real-time core body temperature and activity from small to large animals (80g to 10kg or more) such as Syrian Hamsters, Rats, Ferrets, Pigs, Dogs, or Primates.
Temperature and activity are recorded continuously for up to 150 days in rodents and 285 days in large animals.
These implants are commonly used for infectious disease natural history studies.
When fever or hypothermia is detected, system can send e-mail to preset lists of technicians or directors (for treatment or animal welfare euthanasia criteria), display a flashing warning on monitoring screens and activate a sound alarm on monitoring computers.
In IOX2 acquisition software, onset of fever or hypothermia is detected if current temperature exceeds or decreases below preset thereshol. The threshold can use the Standard Deviation or the raw temperature value as the criteria.
Reliable data in group-housed subjects
» Continuous real-time data storage and display
» Local and remote continuous monitoring and analysis of temperature
» Implants turned on and off remotely
» No need for technicians to ever enter room to record or download data
» Robust design for use in BL3 and BL4 environments
» Group housing of up to 48 subjects in same room
Additional endpoints such as ECG or Blood Pressure are easily added within the same platform.
- Infectious Disease & Medical Countermeasures Research
- Toxicology studies
- Drug development
- Circadian rhythmicity of body temperature and metabolism,
- Chronobiology and sleep research