Check out our interactive booth to find out what’s new at emka TECHNOLOGIES!
New products
2021
We are excited to see the vast number of scientific sessions, courses and posters presented this year!
Be sure to stop by our virtual booth to check out what’s new at emka TECHNOLOGIES!
Cardiovascular toxicity is an important cause of drug attrition, particularly for small molecule projects administered chronically. Electrocardiography (ECG) analysis can provide deep insights into drug-induced myocardial pathology and help mitigate safety liabilities.
While implanted telemetry remains the gold standard for cardiovascular electrophysiology studies, alternative methods have emerged to provide detailed ECG recordings without the use of anesthesia or surgery. For example, repeat-dose toxicity studies can be carried out in large animals with external (jacketed) telemeters to provide a functional assessment of heart rhythm, conduction, repolarization and morphology, without the need for surgery. Jacketed telemetry is often considered more sensitive and reproducible than traditional “snapshot” recordings in restrained animals, which are the mainstay of cardiovascular toxicity studies owing to their cost-effectiveness and highly valuable reference data.
While rats are generally deemed unsuitable for QT interval assessments due to small ventricular hERG-like current, other ECG parameters such as heart rate, PR and QRS intervals can help uncover clinically relevant drug-induced cardiovascular effects. The advent of restrained ECG research platforms suitable for mice, hamsters and rats, coupled with advanced post-processing software, can provide powerful insights into cardiac rhythm abnormalities associated with chronic exposure to drugs. Non-invasive ECG measurements can also reveal effects that intensify on repeated dosing and can therefore replace or complement implanted telemetry studies in exploratory toxicology and repeat-dose toxicity studies.
Contact us to learn more about the benefits and tradeoffs of each technique
Inhaled particulate matter (PM) has recently been linked to a staggering 20% of mortality worldwide.
Studies show chronic inhalation of particulate matter causes alterations in cardiac electrophysiology, and can lead to arrhythmias, oxidative stress, inflammation, vascular dysfunction, atherosclerosis and heart failure. Preexisting cardiovascular disease further increases the risk of adverse cardiac events following chronic PM exposure.
When studying adverse effects of inhaled cardiotoxicants in vivo, incorporating functional cardiovascular outcomes such as electrocardiograms (ECGs) acquired via invasive or non-invasive measurement strategies can offer additional insight.
While implanted telemetry studies remain widely regarded as the gold standard in terms of signal quality, alternative methods have emerged to permit detailed ECG recording without the use of anesthesia or telemetry.
For instance, the ecgTUNNEL, a restrained ECG research platform suitable for mice, hamsters and rats, can record 65% of beats for detailed studies of heart rates, R-R intervals, and QT prolongation. Non-invasive ECG measurements can therefore replace or complement implanted telemetry studies, especially for research involving young mice or fragile knockout models.
2021
The more you can measure, the more you know. Integrating various tools in neuroscience, like video tracking and wireless telemetry, offer a more complete assessment of complex disease models.
In this webinar hosted by Noldus, we will hear about telemetry options in behavioral testing and integration in video tracking experiments. Matt McGuire kindly shares his experiences and insights from his Traumatic Brain Injury (TBI) research at the Dr Poulsen Lab.
MD/PhD Candidate – University at Buffalo Jacobs School of Medicine and Biomedical Sciences.
Title: A rat model of autonomic dysregulation based on heat rate variability following severe traumatic brain injury.
Abstract: Severe traumatic brain injury (TBI) is a leading cause of trauma-related mortality and disability worldwide, affecting about 5.5 million people annually. The autonomic nervous system’s control of cerebral blood flow, and cardiac rhythm are dysregulated following mild TBI or concussion. Autonomic dysfunction after TBI is believed to represent an uncoupling between the cerebral autonomic centers and the cardiovascular system. We evaluated the electrocardiograms (ECG) of adult, male Wistar rats two months following a severe TBI induced by the lateral fluid percussion injury method, to determine if the autonomic system dysregulation observed in human mild TBI can be observed in a preclinical rodent model.
Scientific Sales Specialist at emka TECHNOLOGIES
Chelsea has been with emka TECHNOLOGIES for over three years. She is currently a Scientific Sales Representative for the North American Region, though has worked closely with researchers across the globe. Coming from over 10 years in academic research, Chelsea has experience in a wide array of research topics and with specialization in neuroscience and rodent surgery models. She has been a part of the original team creating and testing the integrated systems between Noldus and emka and continues to assist with future projects of the like.
Title: A look inside the updates in digital telemetry and the benefits to behavioral researchers provided by emka TECHNOLOGIES.
Abstract: Telemetry has continuously morphed over the last several years, becoming more reliable, sensitive, and user friendly. With the additions of synchronized video behavioral phenotypes can be analyzed along with EEG; like sleep stages and seizure liability. The ability to integrate the various disciplines of neuroscience will pave new frontiers for the neuroscience community. Emka TECHNOLOGIES provides telemetry solutions for integrated and synchronous analysis with various behavioral observation, mazes, and tests.
Dominic has been with Noldus for nearly three years. He is currently the Account Manager for the Central Region, though he has worked closely with researchers across the country. He has visited over 100 Noldus labs and has experience with a wide array of different research topics. Dominic was part of the team that first tested the integrated system between Noldus and emka as well as the co-author of the manual that outlines the integration process.
Abstract: EthoVision XT is a software solution for the automated tracking and analysis of animal activity and behavior. In this presentation, I am going to discuss the software as well as demonstrate how it analyzes the videos from Poulsen Lab. Additionally, I will show how the software can easily highlight any significant behavioral or locomotive differences between the experimental groups.
2021
January 14th, 2021
emka TECHNOLOGIES is pleased to announce that we are now approved with Electronic Catalog (ECAT).
ECAT is an easier purchasing method for Department of Defense and other Federal agencies, in the United States of America. This program allows to browse, compare, and order a wide range of laboratory supplies and equipment.
More details can be found here: https://www.dla.mil/TroopSupport/Medical/ECAT/
2021
January 11th, 2021
2021
January 11-13, 2021
Virtual Event
Join us at the SfN Virtual 2021 Meeting, to learn, collaborate and connect with neuroscientist across the globe. We will be available to chat during the event, in Eastern Standard Time (EST). Take a look at the event schedule !
Interested in an integrated approach to traditional preclinical neurophysiology studies?
Wireless telemetry recording systems, paired with synchronized video monitoring, facilitates EEG analysis and behavioral indicators from freely moving single or group housed rodents.
2020
New products
SEND (Standard for Exchange of Nonclinical Data) describes a structured way to submit nonclinical data in a consistent format to U.S. Food and Drug Administration (FDA). SEND aims to improve the efficiency and quality of the Investigative New Drug (IND) and New Drug Application (NDA) processes.
SEND submission is now mandatory for single dose toxicity, repeat-dose toxicity, carcinogenicity, cardiovascular and respiratory studies. However, the flexible interpretation of these guidelines and resulting variability in the output datasets1 can cause delays and inefficiencies in the review process.
As an industry partner with deep expertise in IND-enabling studies, emka TECHNOLOGIES helps nonclinical scientists comply with SEND requirements by generating SEND 3.1 compatible tables directly from emka TECHNOLOGIES software.
The data can easily be exported to .xls, .csv and integrated into third-party solutions by Instem and Xybion to increase productivity in preclinical studies.
2020
As one of the oldest clinical indicators of disease in mammals, temperature is a crucial parameter to monitor, especially for infectious diseases where an acute fever is one of the first symptoms.
Temperature monitoring provides insight into:
» Inflammatory response
» Therapeutic response
» Immunity status and response
» Stress response
Infectious diseases such as COVID-19, influenza, plague, Ebola, and anthrax, affect multiple organ systems with a fever component. In an interview, Brent Barre from Lovelace Biomedical Research Institute explains how he currently works on multiple active SARS-CoV2 studies, using telemetry and plethysmography to look at temperature for onset of fever and respiratory outcomes on various animal models.
The easyTEL implanted telemetry system monitors and captures in real-time core body temperature and activity from small to large animals (80g to 10kg or more) such as Syrian Hamsters, Rats, Ferrets, Pigs, Dogs, or Primates.
Temperature and activity are recorded continuously for up to 150 days in rodents and 285 days in large animals.
These implants are commonly used for infectious disease natural history studies.
When fever or hypothermia is detected, system can send e-mail to preset lists of technicians or directors (for treatment or animal welfare euthanasia criteria), display a flashing warning on monitoring screens and activate a sound alarm on monitoring computers.
In IOX2 acquisition software, onset of fever or hypothermia is detected if current temperature exceeds or decreases below preset thereshol. The threshold can use the Standard Deviation or the raw temperature value as the criteria.
» Continuous real-time data storage and display
» Local and remote continuous monitoring and analysis of temperature
» Implants turned on and off remotely
» No need for technicians to ever enter room to record or download data
» Robust design for use in BL3 and BL4 environments
» Group housing of up to 48 subjects in same room
Additional endpoints such as ECG or Blood Pressure are easily added within the same platform.
2020
2020
2020
Ex vivo studies provide valuable pharmacology insights across many domains.
Isolated organ or tissue systems give researchers complete environmental control (temperature, pressure, flow, perfusate, etc.) and remove the normal homeostatic regulation and whole animal influences. Such systems allow researchers to more quickly and accurately determine cause and effect in the absence of endogenous influence.
Tissue baths or myographs are widely used to study the effects of agonists and antagonists through the measurement of tissue contractility. Dose and concentration response curves allow for quantification of a drug’s pharmacological profile and the calculation of EC50’s.
LEARN MORE & DISCOVER HOW TISSUE BATH ARE USED IN PRECLINICAL RESEARCH
2020
Dear visitor,
Hoping it can help you and be our modest contribution to everybody’s current efforts:
. We offer our IOX and ecgAUTO customers a three-month extra license at no charge, for example to help you working from home or speed-up your current studies.To obtain the license, simply contact us.
If you need a complementary training, we organize on-demand software training: Learn more here
. We stand ready to adapt our sales and delivery processes to special situations and users, for example through hardware and/or software rental or loan. We are also available to provide you with distant help in processing your data.
. We are working with our suppliers to secure our production and limit the risk of stock-outs and delivery delays.
. Our production and logistic teams are maintaining safe distances and clean workspaces to be able to continue to deliver orders made during the current pandemic.
We wish you and your loved one’s the best of health and success in your research.
User presentations
Join us during SOT annual meeting in Anaheim, California for our Exhibitor-Hosted Session:
Alex Carll, Ph.D., M.S.P.H., Assistant Professor at the University of Louisville School of Medicine
The electrocardiogram (ECG) is a valuable tool for assessing cardiac pathophysiology and toxicity in both humans and rodents.
In this hosted session, Dr. Carll will introduce approaches to and reasons for monitoring the ECG during inhalation exposure studies in both mice and rats.
Attendees will learn how to:
Please note that seating is limited.
We therefore encourage you to secure a place at this event by clicking here to access the registration form
![]() Anaheim Convention Center Anaheim, CA 92802, USA |
![]() ![]() Wednesday March 18th, 2020 |
This session is an Exhibitor-Hosted Session. Although not an official part of the SOT Annual Meeting Scientific Program, its presentation is permitted by the Society.
User group
April 2, 2020
Leuven, Belgium
Join us for a day of scientific presentations and discussions to learn more about the flexiVent’s capabilities & flexivent applications and share your feedback with other users.
This user group meeting will be free of charge
Please note that seating is limited.
We therefore encourage you to secure a place at this event by clicking here to access the registration form
WHEN? Thursday April 2, 2020 – Lunch will be provided
WHERE? Leuven, Belgium (Park Inn by Radisson Hotel)
AGENDA:
9:00 a.m. | Registration. |
9:30 a.m. | Welcome and introduction. Frédéric Gagnon – emka TECHNOLOGIES |
9:45 a.m. | SCIREQ flexiVent to Measure Respiratory Mechanics. Kévin DEVIDAL – emka TECHNOLOGIES |
10:30 a.m. | New flexiWare features: reporting, lung volumes. Frédéric Gagnon – emka TECHNOLOGIES |
11:00 a.m | Negative Pressure Forced Expiration perturbation in mouse models of lung disease Dr. Jeroen Vanoirbeek – KU Leuven, Belgium |
11:20 a.m. | Troubleshooting flexiVent Data – Case Study (part 1). Mark Lawrence – SCIREQ Inc. |
11:40 a.m. | Lung function changes in mouse models of COPD Hannelore Van Eeckhoutte – University of Ghent, Belgium |
1:30 p.m. | Drug delivery with the flexiVent Application Mark Lawrence – SCIREQ Inc. |
2:00 p.m. | Impact of chronic exposure to e-cigarette vapors and comparison with cigarette smoke Philippe Gosset – Institut Pasteur Lille |
2:20 p.m. | Whole Body Plethysmograph and large animal studies Jérémy Appell – emka TECHNOLOGIES |
3:00 p.m. | Troubleshooting flexiVent Data – Case Study (Part 2). Mark Lawrence – SCIREQ Inc. |
3:30 p.m. | Open session: General discussion / product & software demonstration. |
4:00 p.m. | Closing Remarks. Frédéric Gagnon – emka TECHNOLOGIES |
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2020
March 5-6, 2020
Bethesda, Maryland – USA
The TBI Research Symposium 2020 is a platform for scientists from local organizations to exchange data and ideas that will advance research and treatment of traumatic brain injury (TBI).
As one of just 4 exhibitors during this symposium, we look forward to show our solutions for Neuro and CNS Research with the focus on TBI.
Animal models of TBI help scientists to study structural damage and functional deficits induced by brain injuries. Several studies demonstrated that long-term functional and structural changes take place up to 1 year after TBI.
emka’s solutions for TBI studies allow short but also long-term acquisition of various physiological parameters (EEG, EMG, blood pressure, respiration, temperature, activity) with:
Visit the symposium website.
User group
June 08–10, 2020
René Remie Surgical Skills Centre
Almere, The Netherlands
Transonic, René Remie Surgical Skills Centre (RRSSC) and emka TECHNOLOGIES are excited to join forces to present the first European Rodent, PV Loop & Cardiac Disease Model Workshop. The Workshop is designed to enable attendees to not only optimize their microsurgical skills, but also gain experience in Admittance-based PV measurements, and be introduced to common cardiac disease models.
Who should attend:
This course is designed for scientists and technicians who are new to rodent pressure-volume recording techniques or those who would like to refine their techniques.
The course will be from June 08-10, 2020 with one optional extra day for the induction of cardiac models (LAD occlusion and TAC).
2019
Please take note that our offices will be closed during holidays:
We wish you happy Holidays and our best wishes for the new year.
Meilleurs voeux!
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