All posts by Sandrine Lemouton

Join us during SPS annual meeting in Barcelona, Spain for our sponsored presentation with Amgen.

Register Now

Leveraging Machine Learning for Automated ECG and Hemodynamic Analyses

Mr Joel Baublits, Senior Associate Scientist at Amgen

  September 24, 2019  –  12:30-1:30 PM  – Room 121

In recent years, cardiovascular safety scientists have adopted a number of analysis software platforms designed to streamline the evaluation of ECG and hemodynamic endpoints.

Post-processing with technologies such as pattern recognition can improve speed and accuracy of analysis using user-defined waveform libraries. While these technologies increase efficiency, the need to evaluate larger datasets (beat to beat), with increased depth (e.g. arrhythmia analysis), presents some conundrums: the need for significant level of human intervention, processing time, and most importantly, can be prone to high inter-user variability, a potential consequence of varying experience and analysis fatigue.

The goal of this study is to leverage historical data to guide a novel pattern recognition algorithm in performing automated ECG and hemodynamic analyses.


Analysis was conducted using a developer build of ecgAUTO (v3.3.5.11, emka TECHNOLOGIES, Paris, France). 

Amgen historical data was used to construct master waveform libraries for multiple assays including conscious non-human primates and conscious/anesthetized beagle dogs. Model waveform selection was based on a composite mode, marking the P, QRS, and T “zones” independently using different waveforms from the master library. 

Reference compound datasets, including known Ikr and Na channel blockers, were used to test the algorithm. New output data was compared with historical data to determine performance.


The algorithm delivered high fidelity data that correlated well with historical analyses, suggesting that this new approach will be able to leverage historical data in a dynamic manner that can scale with increasing data volume. In addition, decreasing manual overreading will result in greater efficiency, delivering high quality data that is less prone to inter-user variability.

This session is a Sponsored Presentation. Although not an official part of the SPS Annual Meeting scientific program, its presentation is permitted by the Society

How to find us at SPS?

Safety Pharmacology 2019 Annual Meeting
September 23- September 26, 2019
Barcelona, Spain
Booth #605


SEND (Standard for Exchange of Nonclinical Data) specifies a way to present nonclinical data in a consistent format, in order to improve exchanges, between 2 data collection systems. Submitting data in SEND format is required by the FDA starting January 2019.

To help you in this challenge, our software suite provides data tables under a SEND 3.1 compatible format for Respiratory, ECG and Vital signs domains. These tables are one of the components of a complete SEND report.

Such tables combined with additional information from Laboratory Information Management System (LIMS), provide you with a complete SEND data solution, from acquisition to submission.

This complete report can be produced by your in-house team or by a third-party solution like submit™-for-SEND from Instem (emka TECHNOLOGIES partner).

As we know that SEND is still an evolving standard, our team continuously adapts to ensure our customer compliance with regulatory guidance.

Download the brochure 

September 28- October 02, 2019
Madrid, SPAIN Booth # V13

The annual European Respiratory Society congress (ERS) will be held in Madrid, bringing together world-class researchers to discuss the latest discoveries in pulmonary research.

Mouse models are of invaluable importance in respiratory research, to understand key disease pathways and for potential assessment of therapeutics for “bench-to-bedside” successes.

The translatability of the data collected requires continuous refinement of the models employed, as well as a holistic approach combining various techniques to provide a comprehensive assessment of the model phenotype.

Asthma and lung inflammation models: from mouse to Man

Join us at booth V13 to discuss pulmonary research applications and highlight our latest developments including:

  • The vivoFlow – WBP (Whole Body Plethysmography) chamber with patented concentric pneumotach design for industry-leading noise cancellation and amber tinted chambers for easily acclimation.
  • Our updated integrated Cigarette Smoking Robot, which is now field-serviceable with more automation and computer-control.

How to find us at ERS?


Event website:

Download the brochure 


emka TECHNOLOGIES has been providing integrated systems for ex vivo preclinical physiology, safety pharmacology and toxicology research, for over 25 years.

Our solutions provide heated, oxygenated and nutrient-rich perfusate to tissues or organs to ensure their survival, while allowing the investigation of vascular and organ function following drug challenges and/or electrical stimulation.

Modular range of solutions

  • Suited to various types of contractile tissues or isolated organs, from different species
  • Switch from tubular to microvessel baths, from Langendorff to Working Heart

View all the products for isolated tissues and organs studies.

Highly reproducible

  • External influences removed
  • No confounding effects from other organs, or neurogenic and hormonal influences

Ease of use

  • Easy to install, use and store
  • For routine use by lab technicians or students
  • Real-time analysis, automated protocols

Focus on new products

emkaMYO2 myograph  

  • Driven manually
  • Equipped with 1 or 2 myograph modules
  • Measures microvessels contractility following drug administration. Learn more.


Liver / kidney / Mesenteric beds perfusion:

  • Especially designed for mice and rats liver, kidney or mesenteric beds perfusion. Learn more.



We are looking for an enthusiastic, motivated individual with an interdisciplinary background combining technical and engineering skills with life sciences to join our Technical Support and Administrative teams.

As the ideal candidate for this position, you have outstanding people and organizational skills and a keen interest to work in a small business environment with a focus on cutting-edge technology.

Working as an EMKA Technical Support Specialist from our office in Falls Church Virginia, you are involved in many facets of our operations, including:

Technical Support Responsibilities:

  • Establish & maintain relations with customers and vendors
  • Analyse, accurately report and solve technical issues (both for software & hardware) for both  customers (external) and sales team (internal)
  • Communicate technical details via email, phone or video conferences to both our customers and head office in Paris, France.
  • Update and maintain ticketing system to track and service support issues
  • Serve as technical expert on EMKA products and software for North America
  • Train employees on hardware, software, and company procedures
  • Participate in quality testing to ensure high quality products
  • Provide mostly remote installation & training via video conferences
  • Travel is available but infrequent for this position.  When travel is needed it would mostly be domestic and Canada.
  • Manage and maintain internal company network infrastructure, servers and computers
  • Perform software validations services (ie: script writing, consulting, installations, etc)
  • Manage software licensing for North America
  • Develop and assist in maintaining required technical documentation
  • Recommend changes or updates in programming, documentation, and training to address system deficiencies and user needs
  • Develop and maintain inventory system

Administrative Responsibilities:

  • Process customer purchase orders, vendors, purchases and customer inventory
  • Fulfill orders
  • Maintain filing system
  • Check orders for accuracy and system fidelity
  • Update products and pricing in CRM as needed
  • Respond to customer service-related issues
  • Manage the production of custom parts with manufacturers
  • Manage incoming and outgoing shipments
  • Manage and organize stock of sellable stock and demo equipment
  • Staffing trade shows when needed
  • Support the team

We offer…

  • A wide variety of responsibilities and challenges
  • A friendly team environment
  • Exciting growth opportunities
  • A pleasant, modern working environment with good compensation and benefits

You possess…                   

  • An interdisciplinary education that combines Engineering and Life Sciences or a related field
  • Technical experience with medical/research equipment or related medical field
  • The ability to learn, analyze and articulate technical information and convey to non-technical and technical people
  • An excellent attention to detail, organization and multi-tasking ability
  • The ability to rapidly learn highly technical information in a dynamic work environment
  • A calm & patient disposition and outstanding customer service skills
  • The ability to work efficiently, both independently and in a team

Education / Qualification Essential


  • Successful completion of a University degree in Engineering, Life Sciences or a related degree
  • Relevant experience in technical support and troubleshooting,
  • Familiarity with the scientific research process (grant applications, conferences, publications)
  • Excellent English skills (written and spoken).


  • Lean Certification and Total Quality System (QMS) preferred
  • Knowledge of cardiovascular physiology and neurophysiology.
  • Prior experience using a technical support ticketing system
  • Prior experience managing a technical support team and associated support or ticketing system
  • Prior technical sales or after-sales experience
  • Prior experience building in-house databases
  • Other spoken languages

How to apply

Please submit your application (including a CV and cover letter in English) online at                      

October 21-23, 2019
René Remie Surgical Skills Centre
Almere, The Netherlands

Transonic, René Remie Surgical Skills Centre (RRSSC) and emka TECHNOLOGIES are excited to join forces to present the first European Rodent, PV Loop & Cardiac Disease Model Workshop. The Workshop is designed to enable attendees to not only optimize their microsurgical skills, but also gain experience in Admittance-based PV measurements, and be introduced to common cardiac disease models.

Established partner Prof. René Remie will share his extensive microsurgical experience and enthusiasm with all attendees by encouraging the best surgical practices – learning the correct techniques and their implementation in attendees’ own laboratories as this course will take place at the René Remie Surgical Skills Centre.

Who should attend:

This course is designed for scientists and technicians who are new to rodent pressure-volume recording techniques or those who would like to refine their techniques.

The course language will be English. The host speaks several languages including: Dutch, English, German and basic French. Therefore, any one-to-one instruction can take place in one’s chosen/native language.

The course will be from October 21 to 23, 2019 with one optional extra day to provide attendees with an opportunity to learn how to introduce a myocardial infarction through ligation of the left anterior descending coronary artery (LAD), or to induce left ventricle hypertrophy by transverse aortic constriction (TAC).

Course fee and registration:

Three-day course fee:  € 1980 (excl VAT).
Additional day: € 660 (excl VAT).

Course fee includes all course materials, coffee & tea, lunch and a group dinner on Day One. Participants will receive a certificate of the training (recognized in most EU countries).

For registration click here.

Thank you for attending the emka User Group Meeting in Wuhan!

It was a pleasure to see you for these evening of scientific presentations and discussions.

The presentation given by Mr. Hai-Ming Tang, Investigator III Preclinical Safety at Novartis Pharmaceutical Corporation during this User Group is available:

Extraction of respiratory rate and stroke volume
information from blood pressure signals in
telemetered dogs


June 22, 2019
Wuhan, China

Join us during the 9th Annual Meeting of Drug Toxicology in Wuhan, for our user group meeting held by Beijing emka Biotechnology Co., Ltd.

This experience exchange meeting will help you to improve your telemetry studies with emka telemetry systems, widely used for animal physiological signal acquisition in pharmacology, safety pharmacology and GLP toxicology in China.

It will also be an opportunity to share your feedback with other users.

WHEN?      June 22, 2019 – 18:30 – 21:30

WHERE?     Wuhan, China (Eurasia International Hotel)


18:00-18:30 Registration
18:30-18:40 Welcome and introduction
Dr. Jufeng Wang,  VP of Beijing Pharmaron
18:40-19:40 Recent Advances in ECG Analysis for ProArrythmia Risk Assessment Simon Authier DVM, MBA, PhD, DSP Deputy Chief Scientific Officer CitoxLab North America
19:40-20:00 Experience using emka telemetry Mr. Hai-Ming Tang, Investigator III Preclinical Safety Novartis Pharmaceutical Corporation
20:00-20:15 Tea break
 20:15-20:45 Detect and analyze non-invasive seizures on dogs Mr. Josh Burton, Vice President of emka TECHNOLOGIES Inc
20:45-21:00 emkaPACK4G with minimally invasive implant for Mini-pig study Shandong Pharmaceutical Academy ,GLP
21:00-21:15 Monkey Long term toxicity Study using emkaPACK4G Mr.  Jiajia Cao, Suzhou CTI  Biotech Co., LTD
21:15-21:30 emkaPACK4G Validation Study on Group Housing Monkey Dr. Jing Lu, Shanghai Material Medical Institute of Chinese Technology Academy
21:30-22:00 Closing Remarks, drinks, lottery and draw game 王海艳、王丹、汪泽峰

In the last 5 years, FDA has actively characterized innovative ECG analysis methods for proarrhythmia assessments in clinical trials. ECG is a cornerstone of cardiac safety monitoring in toxicology and safety pharmacology with similarities between clinical and non-clinical evaluations.

A presentation was given by CitoxLab North America during SOT Annual Meeting & ToxExpo 2019, in Baltimore:

Recent Advances in ECG Analysis for ProArrhythmia Risk Assessment: The Need to Read Between the Line


May 17-22, 2019
Dallas,  Texas – USA
Booth #3619

The ATS Conference is an international platform for respiratory scientists, clinical researchers, medical practitioners and related health care professionals. It provides great networking and engagement opportunities with the emka & SCIREQ team.

Come and meet us at booth 3619 anytime during the exhibition hours. We’d love to learn about your current experimental needs and showcase our latest innovations.


Join us for our annual breakfast event and learn more about preclinical neonate research. Guest speakers from the Morty Lab at Max Planck Institute for Heart and Lung Research in Bad Nauheim, Germany will present their current work on Bronchopulmonary Dysplasia (BDP).

The Morty Lab has two major research themes, both of which relate directly to adult and neonatal critical care medicine. They are currently exploring what causes premature infants to develop BPD when they are ventilated, and new ways to clinically manage this complex and important clinical problem encountered in the neonatal intensive care unit.

Dr. David Surate Solaligue and Dr. Claudio Nardiello from the Morty Lab will present their research in BPD where they successfully used the flexiVent and whole body plethysmography system to measure lung mechanics in BPD pups.

WHEN: Monday May 20, 2019
7 am – 8 am (Doors open at 6:45 am)
WHERE: Courtyard by Marriott Dallas Downtown/Reunion District
310 S Houston St, Dallas, TX 75202 (5 min walk from the convention center)
Meeting Room – Mavericks
AGENDA: 7:00 Welcome & Introduction by David Brunet – SCIREQ
7:10 Measuring How Lungs Work by Dr. Annette Robichaud – SCIREQ
 7:20 Refining Respiratory Mechanic Measurements For Use In Mouse Neonates by Dr. David Surate Solaligue & Dr. Claudio Nardiello – Max Planck Institute, Germany
7:50 Questions & Closing Remarks

April 6-9, 2019
Orlando, Florida – USA
Booth #916

Join the 12 000 scientists that will participate to EB annual meeting and visit our booth to learn more about our latest developments.

This year, we will focus on isolated organs & tissues studies with:

Wire myograph systemsMyo

  • Suitable for the study of microvessels
  • Designed for routine use by lab technicians and students
  • Ideal for cardiovascular & gastrointestinal disease studies

NEW emkaMYO2:
Manually driven and equipped with 1 or 2 myograph modules. Learn more.


Tissue baths systemsTissue-bath-85px

  • Suitable for the study of tissue strips and vessels
  • emkaBATH2: manually driven, compact, easy to use
  • emkaBATH4: fully automated, ability to switch from tubular to microvessel baths 

Perfusion systemsLiver-kidney-85px

  • Designed for research on liver, kidney or mesenteric bed function
  • Ideal for studies of kidney diseases, liver fibrosis, Hepatotoxicity

NEW  Learn more.




Isolated Heart systemsIHS-85px

  • Suitable for mice and rats Langendorff or Working Hearts studies
  • Ideal for safety assessment for IND-enabling studies

How to find us?


April 12-14, 2019
Tokyo – JAPAN

Join us at the 59th Annual Meeting of the Japanese Respiratory Society (JRS) in Tokyo. The program promises three days of interesting sessions, including:

  • Update on pathogenesis in COPD
  • Recent Advances in ARDS
  • Lung injury and repair in pulmonary fibrosis
  • Pathobiology in pulmonary hypertension
  • Sleep apnea

COPD, ARDS, pulmonary fibrosis, pulmonary hypertension and sleep apnea are just some of the research areas where the flexiVent and the plethysmographs has been proven to be the gold standard for in vivo lung function measurement.

We look forward to talks, poster sessions and new collaboration opportunities that will emerge from this meeting.

We hope to see you in Tokyo!

emka TECHNOLOGIES will be exhibiting at the 92nd Annual Meeting of the Japanese Pharmacological Society. This year, the theme is “Concerto on science and innovation toward new horizon of pharmacology “.

Join experts in life science and drug discovery science to discuss collaborations and to attend special lectures and sessions. This will be an opportunity to learn more about emka  solutions for your pharmacological studies:

  • Monitoring physiological data from conscious freely moving large animals using easyTEL+ implantable telemetry systems. Different models are available to meet your study needs, providing monitoring of ECG, EEG, blood pressure, breathing rate, temperature and acceleration from 3-axis accelerometer (activity).
  • Non-invasive options for collecting ECG, blood pressure, breathing rate, temperature, and activity.
  • Ex vivo studies of isolated organs and tissues 

Did you know? Our latest developments on implantable telemetry now allow researchers to remotely set implants to active or sleep mode. Animal can be monitored during several days, with no human interaction!

Join us during SOT Annual Meeting in Baltimore MD, USA for our exhibitor hosted session with Citoxlab.

Recent Advances in ECG Analysis for ProArrhythmia Risk Assessment: The Need to Read Between the Lines.

In the last 5 years, FDA has actively characterized innovative ECG analysis methods for proarrhythmia assessments in clinical trials. ECG is a cornerstone of cardiac safety monitoring in toxicology and safety pharmacology with similarities between clinical and non-clinical evaluations.

The session will compare well established ECG analysis methods used in toxicology with novel strategies that may offer lower false positive rates. Critical success factors in the analysis of pre-clinical ECGs will also be discussed.

The ECG’s acquired during this study were collected by easyTEL+ L EEEETA implanted telemetry. 

WHEN:         March 12, 2018  /  12:00 – 13:00
WHERE:       SOT & ToxExpo 2019, Baltimore Convention Center / Meeting Room 337
SPEAKER:    Dr. Simon Authier – Deputy Chief Scientific Officer, Citoxlab North America

Register Now

2019 SOT Annual Meeting & ToxExpo
March 10-14, 2019
Baltimore MD – USA
Booth 4109 & 4111

How to find us?

SOT 2019 floorplan

April 15-17, 2019
René Remie Surgical Skills Centre
Almere, The Netherlands

Transonic, René Remie Surgical Skills Centre (RRSSC) and emka TECHNOLOGIES are excited to join forces to present the first European Rodent, PV Loop & Cardiac Disease Model Workshop. The Workshop is designed to enable attendees to not only optimize their microsurgical skills, but also gain experience in Admittance-based PV measurements, and be introduced to common cardiac disease models.

Who should attend:

This course is designed for scientists and technicians who are new to rodent pressure-volume recording techniques or those who would like to refine their techniques.

The course will be from April 15-17, 2019 with one optional extra day for the induction of cardiac models (LAD occlusion and TAC).

Interested, for the program click here

For registration click here.

EEG signal acquired in IOX2 software and can be analyzed with our EEG analysis module. It allows scientist to easily:

Epilepsy module in ecgAUTO software
Epilepsy seizure

Sleep scoring
Sleep scoring

Integrated video facilitates behavioral observations without the confounding effects of investigator interaction.

Our secured video data is synchronized with the physiological signal data, allowing the scientist to click on a change in a parameter and observe the associated behavior.

The system features adjustable image resolution, and infrared recording for nighttime observations.

What’s new in EEG analysis module latest version?

In our latest version, the EEG Seizure analysis mode has been redesigned and improved:

  • Seizure summary panel with multiple display modes.
  • Ability to define up to 30 user-settable “hot keys” to add, modify, merge, remove seizures.
  • Direct export of tables into the clipboard from which it directly pastes into excel cells.
  • Ability to display up to 6 FFT spectrums and “freeze” some corresponding to particular time points of the current data file.

FTT spectrum panel
FTT spectrum panel

Seizure panel
Seizure panel

March 4-5, 2019
Bethesda, Maryland – USA

The TBI Research Symposium 2019 is a platform for scientists from local organizations to exchange data and ideas that will advance research and treatment of traumatic brain injury (TBI).

As one of just 6 exhibitors during this symposium, we look forward to show our solutions for Neuro and CNS Research with the focus on TBI.

Animal models of TBI help scientists to study structural damage and functional deficits induced by brain injuries. Several studies demonstrated that long-term functional and structural changes take place up to 1 year after TBI.

emka’s solutions for TBI studies allow short but also long-term acquisition of various physiological parameters (EEG, EMG, blood pressure, respiration, temperature, activity) with:

Visit the symposium website.



March 1-2, 2019
Tokyo, Japan
Booth #G

emka TECHNOLOGIES will be exhibiting at the 10th annual JSPS meeting. Join us to learn more about our solutions for your safety pharmacology studies:

Did you know? Our latest developments on implantable telemetry now allow researchers to remotely set implants to active or sleep mode. Animal can be monitored during several days, with no human interaction!