Join us during SPS annual meeting in Barcelona, Spain for our sponsored presentation with Amgen.

Leveraging Machine Learning for Automated ECG and Hemodynamic Analyses

Mr Joel Baublits, Senior Associate Scientist at Amgen

  September 24, 2019  –  12:30-1:30 PM  – Room 121

In recent years, cardiovascular safety scientists have adopted a number of analysis software platforms designed to streamline the evaluation of ECG and hemodynamic endpoints.

Post-processing with technologies such as pattern recognition can improve speed and accuracy of analysis using user-defined waveform libraries. While these technologies increase efficiency, the need to evaluate larger datasets (beat to beat), with increased depth (e.g. arrhythmia analysis), presents some conundrums: the need for significant level of human intervention, processing time, and most importantly, can be prone to high inter-user variability, a potential consequence of varying experience and analysis fatigue.

The goal of this study is to leverage historical data to guide a novel pattern recognition algorithm in performing automated ECG and hemodynamic analyses.

Methods:

Analysis was conducted using a developer build of ecgAUTO (v3.3.5.11, emka TECHNOLOGIES, Paris, France). 

Amgen historical data was used to construct master waveform libraries for multiple assays including conscious non-human primates and conscious/anesthetized beagle dogs. Model waveform selection was based on a composite mode, marking the P, QRS, and T “zones” independently using different waveforms from the master library. 

Reference compound datasets, including known Ikr and Na channel blockers, were used to test the algorithm. New output data was compared with historical data to determine performance.

Results:

The algorithm delivered high fidelity data that correlated well with historical analyses, suggesting that this new approach will be able to leverage historical data in a dynamic manner that can scale with increasing data volume. In addition, decreasing manual overreading will result in greater efficiency, delivering high quality data that is less prone to inter-user variability.

This session is a Sponsored Presentation. Although not an official part of the SPS Annual Meeting scientific program, its presentation is permitted by the Society

How to find us at SPS?

Safety Pharmacology 2019 Annual Meeting
September 23- September 26, 2019
Barcelona, Spain
Booth #605

September 28- October 02, 2019
Madrid, SPAIN Booth # V13

The annual European Respiratory Society congress (ERS) will be held in Madrid, bringing together world-class researchers to discuss the latest discoveries in pulmonary research.

Mouse models are of invaluable importance in respiratory research, to understand key disease pathways and for potential assessment of therapeutics for “bench-to-bedside” successes.

The translatability of the data collected requires continuous refinement of the models employed, as well as a holistic approach combining various techniques to provide a comprehensive assessment of the model phenotype.

Asthma and lung inflammation models: from mouse to Man

Join us at booth V13 to discuss pulmonary research applications and highlight our latest developments including:

• The vivoFlow – WBP (Whole Body Plethysmography) chamber with patented concentric pneumotach design for industry-leading noise cancellation and amber tinted chambers for easily acclimation.
• Our updated integrated Cigarette Smoking Robot, which is now field-serviceable with more automation and computer-control.

How to find us at ERS?

Event website: https://erscongress.org/

In the last 5 years, FDA has actively characterized innovative ECG analysis methods for proarrhythmia assessments in clinical trials. ECG is a cornerstone of cardiac safety monitoring in toxicology and safety pharmacology with similarities between clinical and non-clinical evaluations.

A presentation was given by CitoxLab North America during SOT Annual Meeting & ToxExpo 2019, in Baltimore:

Recent Advances in ECG Analysis for ProArrhythmia Risk Assessment: The Need to Read Between the Line

May 17-22, 2019
Dallas,  Texas – USA
Booth #3619

The ATS Conference is an international platform for respiratory scientists, clinical researchers, medical practitioners and related health care professionals. It provides great networking and engagement opportunities with the emka & SCIREQ team.

Come and meet us at booth 3619 anytime during the exhibition hours. We’d love to learn about your current experimental needs and showcase our latest innovations.

ARE YOU INTERESTED IN PRECLINICAL NEONATE RESEARCH?

Join us for our annual breakfast event and learn more about preclinical neonate research. Guest speakers from the Morty Lab at Max Planck Institute for Heart and Lung Research in Bad Nauheim, Germany will present their current work on Bronchopulmonary Dysplasia (BDP).

The Morty Lab has two major research themes, both of which relate directly to adult and neonatal critical care medicine. They are currently exploring what causes premature infants to develop BPD when they are ventilated, and new ways to clinically manage this complex and important clinical problem encountered in the neonatal intensive care unit.

Dr. David Surate Solaligue and Dr. Claudio Nardiello from the Morty Lab will present their research in BPD where they successfully used the flexiVent and whole body plethysmography system to measure lung mechanics in BPD pups.

April 6-9, 2019
Orlando, Florida – USA
Booth #916

Join the 12 000 scientists that will participate to EB annual meeting and visit our booth to learn more about our latest developments.

This year, we will focus on isolated organs & tissues studies with:

Wire myograph systems

• Suitable for the study of microvessels
• Designed for routine use by lab technicians and students
• Ideal for cardiovascular & gastrointestinal disease studies

NEW emkaMYO2:
Manually driven and equipped with 1 or 2 myograph modules. Learn more.

Tissue baths systems

• Suitable for the study of tissue strips and vessels
• emkaBATH2: manually driven, compact, easy to use
• emkaBATH4: fully automated, ability to switch from tubular to microvessel baths 

Perfusion systems

• Designed for research on liver, kidney or mesenteric bed function
• Ideal for studies of kidney diseases, liver fibrosis, Hepatotoxicity

NEW  Learn more.

Isolated Heart systems

• Suitable for mice and rats Langendorff or Working Hearts studies
• Ideal for safety assessment for IND-enabling studies

How to find us?

April 12-14, 2019
Tokyo – JAPAN
Booth#46

Join us at the 59th Annual Meeting of the Japanese Respiratory Society (JRS) in Tokyo. The program promises three days of interesting sessions, including:

• Update on pathogenesis in COPD
• Recent Advances in ARDS
• Lung injury and repair in pulmonary fibrosis
• Pathobiology in pulmonary hypertension
• Sleep apnea

COPD, ARDS, pulmonary fibrosis, pulmonary hypertension and sleep apnea are just some of the research areas where the flexiVent and the plethysmographs has been proven to be the gold standard for in vivo lung function measurement.

We look forward to talks, poster sessions and new collaboration opportunities that will emerge from this meeting.

We hope to see you in Tokyo!

emka TECHNOLOGIES will be exhibiting at the 92nd Annual Meeting of the Japanese Pharmacological Society. This year, the theme is “Concerto on science and innovation toward new horizon of pharmacology “.

Join experts in life science and drug discovery science to discuss collaborations and to attend special lectures and sessions. This will be an opportunity to learn more about emka  solutions for your pharmacological studies:

• Monitoring physiological data from conscious freely moving large animals using easyTEL+ implantable telemetry systems. Different models are available to meet your study needs, providing monitoring of ECG, EEG, blood pressure, breathing rate, temperature and acceleration from 3-axis accelerometer (activity).
• Non-invasive options for collecting ECG, blood pressure, breathing rate, temperature, and activity.
• Ex vivo studies of isolated organs and tissues 

Did you know? Our latest developments on implantable telemetry now allow researchers to remotely set implants to active or sleep mode. Animal can be monitored during several days, with no human interaction!

Join us during SOT Annual Meeting in Baltimore MD, USA for our exhibitor hosted session with Citoxlab.

Recent Advances in ECG Analysis for ProArrhythmia Risk Assessment: The Need to Read Between the Lines.

In the last 5 years, FDA has actively characterized innovative ECG analysis methods for proarrhythmia assessments in clinical trials. ECG is a cornerstone of cardiac safety monitoring in toxicology and safety pharmacology with similarities between clinical and non-clinical evaluations.

The session will compare well established ECG analysis methods used in toxicology with novel strategies that may offer lower false positive rates. Critical success factors in the analysis of pre-clinical ECGs will also be discussed.

The ECG’s acquired during this study were collected by easyTEL+ L EEEETA implanted telemetry. 

WHEN:         March 12, 2018  /  12:00 – 13:00
WHERE:       SOT & ToxExpo 2019, Baltimore Convention Center / Meeting Room 337
SPEAKER:    Dr. Simon Authier – Deputy Chief Scientific Officer, Citoxlab North America

2019 SOT Annual Meeting & ToxExpo
March 10-14, 2019
Baltimore MD – USA
Booth 4109 & 4111

How to find us?

March 4-5, 2019
Bethesda, Maryland – USA

The TBI Research Symposium 2019 is a platform for scientists from local organizations to exchange data and ideas that will advance research and treatment of traumatic brain injury (TBI).

As one of just 6 exhibitors during this symposium, we look forward to show our solutions for Neuro and CNS Research with the focus on TBI.

Animal models of TBI help scientists to study structural damage and functional deficits induced by brain injuries. Several studies demonstrated that long-term functional and structural changes take place up to 1 year after TBI.

emka’s solutions for TBI studies allow short but also long-term acquisition of various physiological parameters (EEG, EMG, blood pressure, respiration, temperature, activity) with:

• Implanted & Non-invasive Telemetry
• Plethysmography
• EEG analysis

Visit the symposium website.

March 1-2, 2019
Tokyo, Japan
Booth #G

emka TECHNOLOGIES will be exhibiting at the 10th annual JSPS meeting. Join us to learn more about our solutions for your safety pharmacology studies:

• Physiological data acquisition and analysis, with GLP modules
• Conscious respiratory function measurements
• Wireless implanted telemetry for freely moving group-housed rodents and non-rodents

Did you know? Our latest developments on implantable telemetry now allow researchers to remotely set implants to active or sleep mode. Animal can be monitored during several days, with no human interaction!