Seizure & epilepsy
Seizure is a disorder of the nervous system, thought to be the result of faulty electrical activity in the brain.
Epilepsy studies involve epilepsy seizure detection from EEG traces, but other parameters can be of interest, such as ECG, EMG, activity or sleep scoring.
Indeed, for instance, researches have been suggesting that SUDEP (Sudden Unexpected Death in Epilepsy) could occur preferentially during sleep. Therefore, combining epilepsy and sleep analysis, through a unique analysis software, is a crucial advantage.
Video monitoring, combined with biopotentials acquisition, is also recommended, to identify and characterize movements and give insight to seizure development. EEG and synchronized video acquisition help to identify motor and non-motor seizures or behavioral artifacts.
Wireless technology permits a constant transfer of high volumes of digital data from freely moving animals. The advantages associated with this technique are well established; higher quality data obtained from naturally-behaving subjects, which reliably captures detailed physiological events. Powerful software helps researchers comb through the data and analyze their subject’s response.
Various sized options are available in our implantable telemetry systems, all being able to collect EEG but also ECG, EMG, Blood pressure, temperature and activity continuously during several weeks or months.
Non-invasive telemetry options
Non-invasive systems can also be used to collect neurological and activity changes. Subjects are equipped with an external transmitter housed in a jacket or a helmet. Physiological measurements are captured non-invasively and wirelessly transmitted by Bluetooth, to a receiver.
Our EEG analysis module allows the analysis of EEG morphology with time-synchronized video for behavioral verification.
Automated sleep scoring allows for further behavioral analysis through sleep staging that can be overlaid on signal screen. FFT spectral information can also be overlaid on the signal screen to observe changes between epoch.
Epilepsy detection module
From the EEG signal, the epilepsy module automatically detects epileptic seizures, combining multiple user adjusted criteria and logical modes:
- All detected seizures are logged in a table
- Invalid seizures can be deleted
- Undetected seizures can be created
- Valid seizures can be exported to text or xls files
McGuire, M. J., Gertz, S. M., McCutcheon, J. D., Richardson, C. R., Poulsen, D. J. Use of a Wireless Video-EEG System to Monitor Epileptiform Discharges Following Lateral Fluid-Percussion Induced Traumatic Brain Injury. J. Vis. Exp. (148), e59637, doi:10.3791/59637 (2019).
rodentPACK, head mounted system for rat
ecgAUTO, post-processing software
Implants for rats
Assessment of seizure activity in the telemetered dog: a new procedure using the rodentpack system
Poster presented by Posolt at the Society Of Toxicology meeting, 2017
Cardiac changes in epileptic baboons with high-frequency microburst VNS therapy: A pilot study
de la Garza et al, Epilepsy Research, 2019
Use of a Wireless Video-EEG System to Monitor Epileptiform Discharges Following Lateral Fluid-Percussion Induced Traumatic Brain Injury
McGuire, M.J.et al, J. Vis. Exp. (148), 2019
Surface Lead EEGs: Will It Stick?
Ken Kearney et al, poster presented at the Safety Pharmacology Society, 2018