case studies
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| software for the wireless age |
I want to choose the right software for my research but it's not the easiest of tasks!
Jean-Gérard Napoleoni, Andreas Theodorou, Jonathan Pitcher
In recent years, preclinical research has evolved considerably to exploit the benefits of wireless communications. The most obvious manifestation has … |
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| adapting telemetry setups to large populations |
My telemetry is fantastic, but designing the architecture to make best use of it is another matter!
Jean-Gérard Napoleoni, Andreas Theodorou, Jonathan Pitcher
If the first line has a familiar ring to it, then this article is aimed directly at you. It describes what you should know before you design, bu… |
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| non-invasive ecg for conscious mouse |
non-invasive ecg for conscious mouse
Many of our customers had expressed their desire for a device to non-invasively measure ecg from conscious mice, in order to automate the acquisition process on a large number of subjects.
In response, we designed, developed, extensively tested and launched the ecgTUNNEL, a devi… |
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| conscious/restrained plethysmograph for pig/dog |
CHALLENGE: One of our customers was looking for a plethysmography chamber big enough for mini-pigs, that would also adapt in size as the animal grew. The customer also expressed an interest in making other measurements using catheters while the animal was in the plethysmography chamber.
SOLUTION: We designed, developed, tested in-house, then launched a new |
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| new ecg analysis with old data files |
CHALLENGE: A customer decided to buy a complete ecg acquisition and analysis setup from emka TECHNOLOGIES (iox2 for acquisition and ecg-auto
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| perfusion flow |
CHALLENGE: How can the perfusion rate, and hence amount of product delivered, take into account actual arterial flow from the animal?
SOLUTIONS: As the starting point, we selected a standard perfusion pump from the many models available on the market. We chose a well-established model that offered the possibility of external control by software. We then d… |
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| rejection parameters |
CHALLENGE: When real-time analysis software is connected to freely moving animals (unrestrained plethysmography, telemetry...), a lot of data are generated, not all of which are usable. It would be useful to automatically reject data associated with certain animal behaviors. The original request was to minimise the amount of "sniffing" data lying among … |
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| computed physiological signals |
CHALLENGE: Some signals are not easy to measure directly either because access is limited or because the specific device required is not available. We encountered two such situations in isolated heart experiments (i) coronary flow (not easy to access) and (ii) left ventricular volume (specific device not available).
SOLUTION: The principal was simple: to contruct t… |
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| connecting LIMS |
connecting LIMS - CHALLENGE: acquisition and analysis software such as iox2 generate ever increasing amounts of data for each study: physiological signals, derived parameters, configuration files, audit-trail, etc. Some of these data have to be included in the customer's LIMS (… |
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| automatic flush of inline pressure transducers |
CHALLENGE: When measuring blood pressure from rodents using standard invasive blood pressure transducers, the cathether must be flushed frequently. This operation can become very time-consuming when there are many subjects and/or recording duration is long (for example, a 24-hour recording from 16 subjects).
SOLUTION: The pressure wave amplitude (systolic minus diast… |
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