Cardiotoxicity studies

Preclinical evaluation of cardiotoxicity and clinically relevant electrocardiographic changes related to drug administration are essential for early cardiac safety assessments.

Description

Symptoms of cardiotoxicity may range from slight changes on electrocardiogram to diseases such as cardiac arrhythmias, ischemia or heart failure.

Therefore, performing a fast and reliable analysis of both normal and abnormal ECG complexes is essential. This can be achieved using the shape recognition technique. This technique uses a library of reference waveforms, built by the user for his specific needs. Analysis is carried out on segments of data («steps») defined by protocol linked to original experimental markers.

In ecgAUTO software, specific libraries can be built for different species or leads, allowing a fast and reliable in-depth analysis and detection of HRV, arrhythmia or isolated P waves.